Dozens of people are missing in Oregon alone, with one emergency official saying the state should be preparing for a "mass fatality incident".
Fires have been raging in Oregon, California and Washington for three weeks, burning millions of acres of land and destroying thousands of homes.
Tens of thousands of people have been forced to flee their homes.
Democratic presidential challenger Joe Biden warned on Saturday that "climate change poses an imminent, existential threat to our way of life" and accused President Donald Trump, a climate sceptic, of denying "that reality".
Mr Trump, who is due to visit California on Monday to be briefed on the latest situation, blames the wildfires on poor forest management.
The fires have now scorched an area of land the size of New Jersey, officials say.
In Oregon, where firefighters are battling 16 large blazes, 40,000 people are under mandatory evacuation orders.
Oregon's Office of Emergency Management (OEM) says the fires have killed 10 people, but officials warn the final death toll could be much higher.
Oregon's Fire Marshal Jim Walker resigned on Saturday, shortly after he had been placed on leave amid a personnel investigation.
Earlier this week, Governor Kate Brown implored householders to stay out of the fire zones despite reports of looting.
"Let me assure you that we have the Oregon National Guard and Oregon State Police monitoring the situation and preventing looting," she said
Beatriz Gomez Bolanos, 41, told Reuters news agency of her family's frightening drive to safety through fires burning on both sides of their car. She told her four children to close their eyes as they made their escape.
"Everything is gone. We have to start again from nothing, but we are alive," she told the news agency.
At least one blaze in Oregon - the Almeda Fire, one of the most destructive in the state - is being treated as suspected arson.
In Washington state, firefighters are tackling 15 large fires. A one-year-old boy died earlier this week as his family tried to escape a blaze. His parents remain in a critical condition.
Governor Gavin Newsom, a Democrat, on Friday inspected damage from the North Complex Fire, near Oroville in Northern California.
"The debate is over, around climate change," Mr Newsom told reporters. "This is a climate damn emergency. This is real and it's happening."
He acknowledged failings in forest management in recent decades, but added: "That's one point, but it's not the point."
Highlighting the states effort to combat climate change, he said the record heat waves and unprecedented fires were the sort of problems long forecast by scientists.
President Trump has argued that California could prevent wildfires if it raked forest floors properly.
"You've got to clean your forests - there are many, many years of leaves and broken trees and they're like, so flammable," he told a rally last month. "I've been telling them this now for three years. But they don't want to listen."
The North Complex Fire, which has been burning since 18 August, is among the deadliest in history. Twelve bodies have been found so far and a number of people are still missing.
California has seen at least 22 deaths in total from fires since 15 August. Tens of thousands of people are under evacuation orders as 14,800 firefighters continue to combat 28 major fires in the state.
